Table S7.

DHEA Modulation of Vaccine Efficacy

	Dosage	Timing (before/after vaccination)	Control	Population	Vaccine Type	Outcome	Citation
DHEA	50 mg BID DHEAS (oral) 100mg total daily dosage	4 days, starting 2 days prior to vaccination	50 mg corn starch BID Total daily dose 100mg	Males 65+ years n=66	Tetanus booster	No significant change in vaccine responsea	Araneo et al63
DHEA	50 mg BID DHEA (oral) 100mg total daily dosage	4 days, starting 2 days prior to vaccination	Not specified	61-89 years n=71	TIV	No significant change in vaccine responsea Possible negative effect on vaccine response in individuals without baseline protective antibody titers.	Danenberg et al64
DHEA	7.5 mg subcutaneous DHEAS	Single dose concurrent to vaccination	Vaccination only	73-90 years n=78 Control group consisted of adults <40 years	TIV	Significantly improved serological protection for H3N2 in those with low pre-vaccination titers and lower DHEAS levels, but not other strainsb	Degelau et al65

^aNo significant effect on/association with vaccine response

^bSignificant effect on/association with vaccine response for at least one vaccine strain/subgroup