Figure 1.

Study design of discovery experiment.

Legend: CHUB-S7 cells were treated with a range of B12 conditions – Control: B12 – 500 nM, Low B12: B12 – 0.15 nM, No B12: B12 – 0 nM (n = 3) (Figure 1(a)); control and the addition of a methylation inhibitor 5-aza-2'-deoxycytidine (5-Aza-dc) (Figure 1(b))