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. 2022 Sep 28;11(1):2275–2287. doi: 10.1080/22221751.2022.2117098

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Spike determinants for the altered entry mechanism of Omicron BA.1 and BA.2. A-D. 293T cells were transfected with hACE2 or co-transfected with hACE2 and TMPRSS13 (A), TMPRSS11D (B), Cathepsin L (C), or Cathepsin B (D), followed by transduction with pseudoviruses expressing the indicated spike at 24 h post-transfection. Pseudovirus entry was quantified by measuring the luciferase signal (n = 4). Fold changes in the luciferase signal were normalized to the mean luciferase readouts of cells with only hACE2 overexpression. Data represent mean ± SD from the indicated number of biological repeats. Statistical significance was determined with one way-ANOVA. Data were obtained from three independent experiments. Each data point represents one biological repeat. * represented p < 0.05, ** represented p < 0.01, *** represented p < 0.001, and **** represented p < 0.0001. ns, not statistically significant.