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. 2022 Sep 28;11(1):2275–2287. doi: 10.1080/22221751.2022.2117098

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — The H655Y substitution in Omicron BA.1 and BA.2 spike promotes endosomal entry. (A–B) VeroE6-TMPRSS2 cells were pre-treated with 1, 25, or 50μM camostat (A) or E64D (B) or DMSO (A–B) for 2 h followed by transduction with pseudoviruses expressing the indicated spike at 24 h post-transfection. Pseudovirus entry was quantified by measuring the luciferase signal (n = 5 for camostat treatment of Omicron BA.1, S₁/S₂-10Del, S₁/S₂-AAAA, and H655Y; n = 4 for the other groups). Data represent mean ± SD from the indicated number of biological repeats. Statistical significances were determined with one way-ANOVA. Data were obtained from three independent experiments. Each data point represents one biological repeat. * represented p < 0.05, ** represented p < 0.01, *** represented p < 0.001, and **** represented p < 0.0001. ns, not statistically significant.