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. 2022 Oct 3;11(1):2127284. doi: 10.1080/2162402X.2022.2127284

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Current techniques to therapeutically target TAMs include (a) involvement of TAMs in current immune checkpoint inhibition; (b) reducing recruitment of macrophages to the TME, e.g. by blocking CCR2/CCL2 and CSF-1/CSFR1 pathways; (c) inhibiting pro-tumor functions of TAMS; (d) promoting antitumor functions of TAMS; (e) depleting specific pro-tumor subsets of TAMs; (f) repolarizing TAMs through the engagement of their FcRs, triggering downstream activation, increased secretion of pro-inflammatory cytokines and enhanced cancer cell death. Created with BioRender.com.