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. 2022 May 24;151(7):993–1004. doi: 10.1002/ijc.34050

FIGURE 2.

FIGURE 2

ROC curve for the S5 classifier for CIN3+ vs <CIN3, CIN2+ vs <CIN2 and CIN2 vs <CIN2 endpoints restricted to biopsied hrHPV positive women with abnormal cytology, re‐weighted to represent hrHPV positive biopsied women (n = 3797). See Table S1 for AUC values for other comparisons. Point estimates are also given for HSIL+ or ASC‐H cytology, HPV16 and HPV18 genotyping (separately) and S5 at 0.8 and 1.4 cut‐offs.

Receiver operator characteristic (ROC) curves showing the diagnostic ability of S5 methylation for outcomes CIN3+, CIN2+ and CIN2 separately. Sensitivity and specificity are also plotted for HSIL+ or ASC‐H cytology, HPV16 and HPV18 genotyping (separately) and S5 at 0.8 and 1.4 cut‐offs. AUC is calculated for outcomes CIN3+, CIN2+ and CIN2.

AUC, area under the curve; CIN2, cervical intraepithelial neoplasia grade 2 [CIN2] or greater [CIN2+]; CIN3, cervical intraepithelial neoplasia grade 3 [CIN3] or greater [CIN3+]; hrHPV, high‐risk human papillomavirus; HSIL, high‐grade squamous intraepithelial lesions or greater [HSIL+]