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. 2022 Sep 28;23(1):1–15. doi: 10.1080/15384047.2022.2125748

Figure 4.

Figure 4.

MZ1 blocks the AML cells cycle and promotes apoptosis. (a) PI-labeled cell cycle analysis after 12–24 h treatment of NB4, Kasumi-1, MV4-11 and K562 cell lines with DMSO or MZ1 revealed that AML cells were distributed in the G1/S phase and the cell population in the G1 phase was significantly increased. (b) A dose-dependent increase in apoptosis was observed in AML cell lines after 24 h of MZ1 treatment. Each concentration was tested in triplicate and independently performed at least three times. *p < .05, **p < .01, ***p < .001, ****p < .0001.