TABLE 1.
Characteristics of the case and control groups
| Characteristics |
Cases N = 25,216 n (%) |
Controls N = 126,080 n (%) |
|---|---|---|
| Sex at birth, female | 18,892 (74.9) | 94,460 (74.9) |
| Age, years, mean (SD) | 57.5 (13.5) | 57.5 (13.5) |
| Age group | ||
| 0–19 | 128 (0.5) | 640 (0.5) |
| 20–34 | 1021 (4.1) | 5105 (4.1) |
| 35–44 | 3132 (12.4) | 15,660 (12.4) |
| 45–54 | 6132 (24.3) | 30,660 (24.3) |
| 55–64 | 6552 (26.0) | 32,760 (26.0) |
| 65–74 | 5570 (22.1) | 27,850 (22.1) |
| 75–84 | 2421 (9.6) | 12,105 (9.6) |
| ≥85 | 260 (1.0) | 1300 (1.0) |
| Area of residence a | ||
| Paris area (Ile‐de‐France) | 4331 (17.2) | 21,655 (17.2) |
| Northeast | 4842 (19.2) | 24,210 (19.2) |
| Northwest | 5000 (19.8) | 25,000 (19.8) |
| Southeast | 5755 (22.8) | 28,775 (22.8) |
| Southwest | 4802 (19.0) | 24,010 (19.0) |
| French overseas area | 486 (1.9) | 2430 (1.9) |
| Year of surgery | ||
| 2009 | 2070 (8.2) | |
| 2010 | 2220 (8.8) | |
| 2011 | 2299 (9.1) | |
| 2012 | 2464 (9.8) | |
| 2013 | 2469 (9.8) | |
| 2014 | 2639 (10.5) | |
| 2015 | 2628 (10.4) | |
| 2016 | 2762 (10.9) | |
| 2017 | 2742 (10.9) | |
| 2018 | 2923 (11.6) | |
| Anatomic location of the meningioma | ||
| Anterior skull base | 5285 (20.9) | |
| Middle skull base | 4790 (19.0) | |
| Posterior skull base | 2770 (11.0) | |
| Convexity | 9554 (37.9) | |
| Falx and tentorium | 2608 (10.3) | |
| Other locations | 209 (0.8) | |
| Tumour grade ICD‐10 | ||
| Benign (D32) | 23,010 (91.3) | |
| Sex, female | 17,429 (75.7) | |
| Atypical (D42) | 1587 (6.3) | |
| Sex, female | 1101 (69.4) | |
| Malignant (C70) | 619 (2.4) | |
| Sex, female | 362 (58.5) | |
| Adjuvant radiation therapy | ||
| All grades | 2274 (9.0) | |
| Benign (D32) | 1917 (8.3) | |
| Atypical (D42) | 145 (9.1) | |
| Malignant (C70) | 212 (34.2) | |
| Death, according to tumour grade, within 2 years (N = 25,216) b | ||
| All grades | 854 (3.4) | |
| Benign (D32) | 692 (3.0) | |
| Atypical (D42) | 70 (4.4) | |
| Malignant (C70) | 92 (14.8) | |
| Within 5 years (N = 16,789) c | ||
| All grades | 1152 (6.8) | |
| Benign (D32) | 971 (6.3) | |
| Atypical (D42) | 91 (8.5) | |
| Malignant (C70) | 90 (25.5) | |
Abbreviations: ICD‐10, International Classification of Diseases, Tenth Revision; Sex, female, individuals born female.
Northeast: Grand Est, Bourgogne Franche‐Comté, Hauts‐de‐France. Paris area (Ile‐de‐France): Paris city and Ile‐de‐France area. Northwest: Bretagne, Centre Val de Loire, Normandie, Pays de la Loire. Southeast: Auvergne‐Rhône‐Alpes, Provence‐Alpes‐Côte d'Azur, Corse. Southwest: Nouvelle‐Aquitaine, Occitanie. French overseas area: Guadeloupe, Martinique, French Guiana, Reunion Island.
Death within 2 years: for the entire cohort, deaths from any cause were identified from the index date until 2 years after this date.
Death within 5 years: deaths from any cause were identified from the index date until 5 years later for all cases undergoing meningioma surgery before 1 January 2016.