TABLE 3.
Association between surgically treated meningioma and exposure to progestogens according to age, sex at birth, tumour grade and site; estimated OR and 95% CI
| Exposure | Any of the three progestogens | Cyproterone acetate | Nomegestrol acetate | Chlormadinone acetate |
|---|---|---|---|---|
| Sex, female | ||||
| Overall | 6.6 (6.3–7.1) | 19.7 (17.0–22.7) | 4.7 (4.3–5.1) | 3.3 (3.0–3.6) |
| 0–19 | 5.0 (0.3–79.9) | 5.0 (0.3–79.9) | ||
| 20–34 | 5.4 (4.0–7.2) | 12.6 (8.0–19.8) | 3.1 (1.8–5.5) | 2.0 (1.1–3.5) |
| 35–44 | 6.0 (5.2–6.8) | 21.9 (16.4–29.2) | 3.5 (2.9–4.3) | 2.6 (2.1–3.3) |
| 45–54 | 6.3 (5.8–6.9) | 18.7 (15.0–23.4) | 4.6 (4.1–5.2) | 3.6 (3.2–4.0) |
| 55–64 | 8.9 (7.5–10.6) | 21.8 (14.8–32.0) | 7.1 (5.5–9.0) | 4.1 (3.0–5.7) |
| ≥65 years old | 10.6 (7.7–14.6) | 27.9 (15.1–51.6) | 7.7 (4.8–12.3) | 1.8 (0.7–4.5) |
| Sex, male | ||||
| Overall | 8.0 (5.2–12.3) | 8.0 (5.2–12.3) | ||
| <65 years old | 12.5 (5.5–28.4) | 12.5 (5.5–28.4) | – | |
| ≥65 years old | 6.6 (4.0–11.0) | 6.6 (4.0–11.0) | ||
| Tumour grade ICD‐10 | ||||
| Benign (D32) | 6.7 (6.2–7.1) | 18.4 (15.9–21.2) | 4.7 (4.3–5.1) | 3.3 (3.0–3.6) |
| Sex, female | 6.6 (6.2–7.1) | 19.5 (16.7–22.7) | 4.7 (4.3–5.1) | 3.3 (3.0–3.6) |
| Sex, male | 9.1 (5.7–14.6) | 9.1 (5.7–14.6) | ||
| Atypical (D42) | 7.1 (5.5–9.2) | 21.6 (12.1–38.6) | 4.6 (3.2–6.7) | 3.3 (2.2–4.9) |
| Sex, female | 7.0 (5.4–9.1) | 21.7 (11.9–39.7) | 4.6 (3.2–6.7) | 3.3 (2.2–4.9) |
| Sex, male | 20.0 (2.2–178.9) | 20.0 (2.2–178.9) | ||
| Malignant (C70) | 6.1 (3.8–9.8) | 14.3 (6.0–33.8) | 4.9 (2.2–10.8) | 2.8 (1.3–5.9) |
| Sex, female | 6.6 (4.0–10.8) | 23.7 (8.1–69.8) | 4.9 (2.2–10.8) | 2.8 (1.3–5.9) |
| Sex, male | 1.7 (0.2–16.0) | 1.7 (0.2–16.0) | ||
| Anatomic location | ||||
| Anterior skull base | 10.2 (8.9–11.6) | 35.7 (26.5–48.2) | 6.2 (5.2–7.4) | 3.5 (2.9–4.4) |
| Middle skull base | 9.7 (8.6–11.1) | 23.9 (17.8–32.2) | 6.8 (5.7–8.1) | 4.7 (3.9–5.7) |
| Posterior skull base | 2.9 (2.4–3.6) | 6.4 (3.9–10.4) | 2.6 (1.9–3.5) | 2.1 (1.5–2.9) |
| Convexity | 5.1 (4.6–5.7) | 12.4 (9.9–15.5) | 3.5 (3.0–4.2) | 2.9 (2.4–3.4) |
| Falx and tentorium | 3.5 (2.8–4.5) | 10.4 (6.2–17.4) | 2.8 (1.9–3.9) | 2.0 (1.3–3.0) |
Abbreviations: CI, confidence interval; ICD‐10, International Classification of Diseases, Tenth Revision; OR, odds ratio, controlling for matching factors (sex at birth, year of birth and area of residence); Sex, female, individuals born female.