Condition	First line treatment	GRADE58	Second line treatment	GRADE58
Impetigo59	Peroral trimethoprim–sulfamethoxazole twice a day for 3 days or once a day for 5 days; or intramuscular benzathine penicillin G	1A	Peroral amoxicillin three times per day for 7 days; or peroral erythromycin four times per day for 7 days	2B
Scabies59	Topical permethrin on Day 1 and Day 8 for the index patient and household contacts	1A	Peroral ivermectin on Day 1 and Day 8 for the index patient who has failed treatment with topical permethrin within the preceding 4 weeks	1B
Cellulitis60	Intravenous β‐lactam for up to 2 days (for severe cellulitis only) followed by oral β‐lactam (eg, cephalexin four times per day for a total of 5 days)	1A	Peroral trimethoprim–sulfamethoxazole twice a day for 5 days; or peroral clindamycin three times per day for 5 days	1B
Abscesses60	Incision and drainage; followed by peroral clindamycin three times per day for 5 days; or peroral trimethoprim–sulfamethoxazole twice a day for 5 days	1A

^*  GRADE definitions: 1A: Strong recommendation, applies to most patients without reservation. 1B: Strong recommendation, applies to most patients. 2B: Weak recommendation, alternative approaches are likely to be better for some patients under some circumstances.