Table 1.

Characteristics and structure of the human TM

Layer	Location	Thickness (μm)	Morphology	ECM composition	Cell type	Authors
Uveoscleral meshwork	Extends from the iris root and ciliary body to the Schwalbe's line	25–27	3–4 beam layers. Open spaces between beams Highly porous	Collagen I, III and elastic fibers	Endothelium macrophage	Tamm (2009), Tamm and Fuchshofer (2007),Buffault et al. (2020)
Corneoscleral meshwork	From the anterior wall of the scleral sulcus to the scleral spur	2–15	8–15 layers. Open spaces between beams Highly fenestrated structure and porosity	Collagen I, III and elastic fibers	Endothelium macrophage	Tamm (2009),Grant (1958), Tamm and Fuchshofer (2007),Buffault et al. (2020)
Juxtacanalicular meshwork	Its outermost portion corresponds to the inner wall of SC	2–20	2–5 layers of scattered cells Compact and amorphous	Covered with an endothelial layer, elastic fibers of collagen IV, laminin, fibronectin, hyaluronic acid	Fibroblast smooth muscle cell	Grant (1958), Tamm (2009),Gong et al. (1992),Buffault et al. (2020)

Abbreviations: ECM, extracellular matrix; SC, Schlemm's canal; TM, trabecular meshwork.