TABLE 3.

Comparison of correlation analysis between manual and automated segmentation techniques (FSL‐FIRST, FreeSurfer)

	FSL‐FIRST			FreeSurfer
	Default	Fast	None
PCC
L‐hippocampus	0.83	0.83	0.86	0.47
R‐hippocampus	0.74	0.74	0.75	0.54
L‐amygdala	0.61	0.61	0.67	0.34
R‐amygdala	0.66	0.66	0.67	0.47
L‐thalamus	0.86	0.87	0.86	0.60
R‐thalamus	0.89	0.88	0.89	0.61
L‐putamen	0.98	0.97	0.98	0.82
R‐putamen	0.98	0.96	0.98	0.84
L‐GP	0.94	0.89	0.94	0.49
R‐GP	0.92	0.87	0.92	0.52
L‐caudate	0.78	0.78	0.69	0.84
R‐caudate	0.87	0.87	0.80	0.80
L‐accumbens	0.69	0.69	0.77	0.44
R‐accumbens	0.81	0.81	0.76	0.56
L‐cau + acc	0.77	0.77	0.70	0.83
R‐cau + acc	0.85	0.85	0.78	0.81
Combined mean	0.83	0.82	0.82	0.60
ICC (A, k)
L‐hippocampus	0.75	0.75	0.34	0.20
R‐hippocampus	0.68	0.68	0.28	0.23
L‐amygdala	0.55	0.55	0.29	0.09
R‐amygdala	0.58	0.58	0.31	0.07
L‐thalamus	0.66	0.72	0.66	0.66
R‐thalamus	0.69	0.70	0.69	0.66
L‐putamen	0.93	0.95	0.93	0.84
R‐putamen	0.90	0.92	0.90	0.82
L‐GP	0.82	0.53	0.82	0.26
R‐GP	0.85	0.46	0.85	0.39
L‐caudate	0.85	0.85	0.37	0.90
R‐caudate	0.89	0.89	0.53	0.85
L‐accumbens	0.69	0.69	0.33	0.58
R‐accumbens	0.65	0.65	0.31	0.27
L‐cau + acc	0.87	0.87	0.31	0.91
R‐cau + acc	0.91	0.91	0.43	0.90
Combined mean	0.75	0.71	0.54	0.49

Notes: Pearson correlation coefficients (PCC) and intraclass correlation coefficients (ICC) (A, k) computed between manual and automatic segmentation volumes. P‐values for PCC were on all structures p < 0.001.

Abbreviations: Cau + acc, combined volume of the caudate and nucleus accumbens; Combined mean, mean of all structures combined; GP, globus pallidus; L, left; R, right.