Table 1.
AD Patient and HV Demographics and Clinical Characteristics at Baseline
| AD Patients, n = 60 | HV, n = 21 | p | |
|---|---|---|---|
| Age, years, mean (SD) | 74.11 (6.12) | 71.19 (6.31) | p > 0.05 |
| Sex, females, n (%) | 38 (63%) | 12 (57%) | p > 0.05 |
| Education, years, mean (SD) | 8.52 (4.11) | 10.04 (4.98) | p > 0.05 |
| RMT, % stimulator output, mean (SD) | 51.52 (8.82) | 58.25 (5.70) | p < 0.05 |
| Proportion of patients taking cholinesterase inhibitors, n (%) | 46 (76%) | ||
| Proportion of patients taking memantine, n (%) | 12 (20%) | ||
| APOE e4 carrier, n (%) | 31 (52%) | – | ‐ |
| MMSE raw score, mean (SD) | 22.10 (3.11) | 28.81 (1.86) | p < 0.05 |
| CDR‐SB raw score, mean (SD) | 3.99 (1.64) | – | – |
| ADAS‐Cog raw score, mean (SD) | 21.95 (6.91) | – | – |
| ADCS‐ADL score, mean (SD) | 60.85 (10.85) | – | – |
| NPI score, mean (SD) | 11.98 (11.22) | – | – |
| FAB raw score, mean (SD) | 11.42 (3.29) | – | – |
AD = Alzheimer disease; ADAS‐Cog = Alzheimer's Disease Assessment Scale–Cognitive Subscale; ADCS‐ADL = Alzheimer's Disease Cooperative Study–Activities of Daily Living; CDR‐SB = Clinical Dementia Rating Scale Sum of Boxes; FAB = Frontal Assessment Battery; HV = healthy volunteer; MMSE = Mini‐Mental State Examination; NPI = Neuropsychiatric Inventory; RMT = resting motor threshold; SD = standard deviation.