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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Adv Ther (Weinh). 2022 Jun 17;5(8):2200018. doi: 10.1002/adtp.202200018

Figure 1. Synthesis and characterization of Chitosan-β-Cyclodextrin (CS-CD) di-block copolymer coated gold NPs.

Figure 1.

(a) Schematic illustration of uPA-targeted, CS-CD coated gold nanostar (pAuNS), and nanodot (AuND) NPs loaded with therapeutic miRs and a plasmid coding for TK-p53-NTR triple therapeutic gene; (b) Hydrodynamic sizes and surface charges of AuNS and AuND with and without loaded miRs/pTK-p53-NTR by dynamic light scattering (DLS) measurements (n=3, the data are presented as mean ± SD); (c) DNA loading efficiency of AuNS and AuND NPs at multiple concentrations based DNA/NPs ratio measured using the gel retardation assay; (d) Transfection efficiency of three different gold NPs estimated using delivery of Fluc-eGFP-pcDNA reporter plasmid (eGFP-pcDNA) by bioluminescence imaging and its quantitative graph (e), (n=3, the data are presented as mean ± SD).