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. 2021 Dec 6;18(8):1545–1564. doi: 10.1002/alz.12511

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© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Hypothetical model integrating the National Institute on Aging (NIA) Health Disparities Research Framework with the amyloid/tau/neurodegeneration (AT[N]) criteria from the NIA–Alzheimer's Assocation Research Framework. Evidence supporting individual examples association with Alzheimer's disease biomarkers is hypothetical in some instances. Examples are generally categorized as environmental, sociocultural, behavioral, or biological factors. However, we acknowledge that many examples can belong in multiple categories