TABLE 2.
Secondary endpoints (induction time, insert time, fully alert time, recovery time and top‐up doses)
| Variable | Ciprofol | Propofol | ||||
|---|---|---|---|---|---|---|
| Colonoscopy (n = 129) | Gastroscopy (n = 15) | Colonoscopy and gastroscopy (n = 144) | Colonoscopy (n = 130) | Gastroscopy (n = 15) | Colonoscopy and gastroscopy (n = 145) | |
| Induction time (min) | ||||||
| Mean ± SD | 1.1 ± 0.4 | 1.2 ± 0.8 | 1.1 ± 0.5 | 1.1 ± 0.4 | 1.0 ± 0.2 | 1.1 ± 0.4 |
| Median (min, max) | 1.0 (0.5, 3.3) | 1.0 (0.5, 3.0) | 1.1 (0.5, 3.3) | 1.0 (0.5, 3.5) | 1.0 (0.5, 1.2) | 1.0 (0.5, 3.5) |
| P value a | 0.218 | 0.499 | 0.405 | |||
| Insert time (min) | ||||||
| Mean ± SD | 1.5 ± 0.5 | 1.6 ± 0.8 | 1.5 ± 0.5 | 1.5 ± 0.5 | 1.2 ± 0.2 | 1.5 ± 0.5 |
| Median (min, max) | 1.3 (0.8, 3.6) | 1.5 (0.8, 3.4) | 1.4 (0.8, 3.6) | 1.3 (0.6, 3.6) | 1.3 (0.7, 1.5) | 1.3 (0.6, 3.6) |
| P value a | 0.504 | 0.081 | 0.911 | |||
| Fully alert time (min) | ||||||
| Mean ± SD | 3.2 ± 3.2 | 4.4 ± 2.3 | 3.3 ± 3.1 | 1.8 ± 2.0 | 3.0 ± 2.7 | 2.0 ± 2.1 |
| Median (min, max) | 2.0 (0.0, 13.0) | 4.0 (0.2, 9.2) | 2.0 (0.0, 13.0) | 1.0 (0.1, 3.0) | 3.0 (0.1, 11.0) | 1.1 (0.0, 13.0) |
| P value a | < 0.001 | 0.070 | < 0.001 | |||
| Recovery time (min) | ||||||
| Mean ± SD | 7.2 ± 3.2 | 8.4 ± 2.3 | 7.4 ± 3.1 | 5.8 ± 2.0 | 7.1 ± 2.8 | 6.0 ± 2.1 |
| Median (min, max) | 6.0 (3.9, 17.0) | 8.0 (4.0, 13.1) | 6.0 (3.9, 17.0) | 5.1 (4.0, 17.0) | 7.0 (4.0, 15.0) | 5.1 (4.0, 17.0) |
| P value a | < 0.001 | 0.076 | < 0.001 | |||
| Top‐up dosing times (n) | ||||||
| Median (min, max) | 0.0 (0.0, 7.0) | 0.0 (0.0, 2.0) | 0.0 (0.0, 7.0) | 1.0 (0.0, 3.0) | 0.0 (0.0, 1.0) | 1.0 (0.0, 3.0) |
| P value a | 0.052 | 0.150 | 0.136 | |||
| Top‐up doses required | ||||||
| No | 74 (57.4%) | 11(73.3%) | 85 (59.0%) | 58 (44.6%) | 14 (93.3%) | 72 (49.7%) |
| Yes | 55 (42.6%) | 4 (26.7%) | 59 (41.0%) | 72 (56.4%) | 1 (6.7%) | 73 (50.3%) |
| P value a | 0.193 | 0.132 | 0.340 | |||
Note: Insert time: colonoscopy or gastroscopy insertion; fully alert time: from colonoscope withdrawal to full alertness; recovery time: from colonoscope withdrawal to patient discharge.
a
Ciprofol compared to propofol.