TABLE 4.

Diagnostic Performance of Tumor Volume and Monoexponential, SEM, and IVIM Parameters in Predicting NACT Treatment Outcomes

Parameter	Pretreatment (n = 37)			After One Cycle of NACT (n = 37)			After Three Cycles of NACT (n = 35)
	AUC	95% Confidence Interval	P	AUC	95% Confidence Interval	P	AUC	95% Confidence Interval	P
Tumor volume (cm3)	0.838	0.707–0.969	<0.001	0.868	0.747–0.989	<0.001	0.872	0.756–0.987	<0.001
ADC (×10−3 mm2 s−1)	0.582	0.393–0.772	0.39	0.521	0.326–0.715	0.83	0.503	0.307–0.699	0.97
DDC (×10−3 mm2 s−1)	0.579	0.391–0.768	0.41	0.508	0.312–0.706	0.92	0.520	0.325–0.715	0.84
α (unitless)	0.585	0.396–0.774	0.37	0.732	0.564–0.901	0.01	0.595	0.392–0.798	0.34
D t (×10−3 mm2 s−1)	0.541	0.351–0.761	0.67	0.526	0.333–0.720	0.78	0.587	0.395–0.788	0.38
D p (×10−3 mm2 s−1)	0.509	0.313–0.705	0.92	0.662	0.478–0.845	0.09	0.628	0.429–0.827	0.20
f (%)	0.664	0.488–0.842	0.08	0.726	0.555–0.898	0.01	0.628	0.424–0.832	0.20
f × D p (×10−3 mm2 s−1)	0.620	0.438–0.803	0.21	0.744	0.582–0.906	0.01	0.670	0.481–0.859	0.09

Statistically significant results are highlighted in bold font. SEM = stretched‐exponential model; IVIM = intravoxel incoherent motion; NACT = neoadjuvant chemotherapy; AUC = Area under the receiver operating characteristic curve; ADC = apparent diffusion coefficient; DDC = distributed diffusion coefficient; α = diffusion heterogeneity index; D _t  = tissue diffusion; D _p  = pseudo‐diffusion coefficient; f = perfusion fraction.