Table 1.
Preoperative multivariable logistic regression analysis for prediction of lymph node involvement, pT3/4 disease, and any NOCD in 1029 patients treated with RC for UC of the bladder
| Characteristic | Lymph node involvement | pT3/4 disease | Any NOCD | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P‐value | OR | 95% CI | P‐value | OR | 95% CI | P‐value | |
| IGF‐1 levels in μg/cL | 1.12 | 0.89, 1.40 | 0.3 | 1.06 | 0.86, 1.29 | 0.6 | 1.07 | 0.88, 1.31 | 0.5 |
| IGFBP‐2 levels μg/cL | 0.59 | 0.51, 0.68 | <0.001* | 0.91 | 0.82, 1.00 | 0.052 | 0.81 | 0.73, 0.89 | <0.001* |
| IGFBP‐3 levels μg/dL | 0.68 | 0.57, 0.81 | <0.001* | 0.87 | 0.75, 1.01 | 0.076 | 0.88 | 0.76, 1.03 | 0.11 |
| Age | 1.00 | 0.98, 1.01 | 0.7 | 1.03 | 1.01, 1.04 | <0.001* | 1.02 | 1.01, 1.03 | 0.003* |
| Female sex (ref: male) | 1.38 | 0.96, 1.97 | 0.077 | 1.03 | 0.75, 1.42 | 0.8 | 1.13 | 0.82, 1.55 | 0.5 |
| Clinical tumor stage (ref: cTa/cTis/cT1) | |||||||||
| cT2 | 2.57 | 1.86, 3.57 | <0.001* | 2.70 | 2.06, 3.57 | <0.001* | 3.03 | 2.32, 3.98 | <0.001* |
| cT3/cT4 | 3.61 | 2.00, 6.45 | <0.001* | 9.01 | 5.06, 16.8 | <0.001* | 8.51 | 4.65, 16.5 | <0.001* |
| AUC of the full model (all variables included) | 72.9* | 68.8* | 70.1* | ||||||
| AUC of the model without biomarkers levels (reference model) | 62.9* | 67.5* | 67.6* | ||||||
| Additive value of biomarkers in %; P = difference to full model | 10% (P < 0.001)* | 1.3% (P = 0.024)* | 2.5% (P = 0.003)* | ||||||
*
Statistically significant value.