Table 2.
Preoperative multivariable cox regression analysis for prediction of RFS, CSS, and OS in 1029 patients treated with RC for UC of the bladder
| Characteristic | RFS | CSS | OS | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P‐value | HR | 95% CI | P‐value | HR | 95% CI | P‐value | |
| IGF‐1 levels in μg/cL | 1.07 | 0.91, 1.25 | 0.4 | 1.09 | 0.93, 1.28 | 0.3 | 1.13 | 1.00, 1.27 | 0.054 |
| IGFBP‐2 levels μg/cL | 0.78 | 0.71, 0.86 | <0.001* | 0.77 | 0.69, 0.85 | <0.001* | 0.87 | 0.81, 0.93 | <0.001* |
| IGFBP‐3 levels μg/dL | 0.78 | 0.68, 0.88 | <0.001* | 0.74 | 0.64, 0.84 | <0.001* | 0.88 | 0.80, 0.97 | 0.009* |
| Age | 1.02 | 1.00, 1.03 | 0.008* | 1.02 | 1.01, 1.03 | <0.001* | 1.05 | 1.04, 1.06 | <0.001* |
| Female sex (ref: male) | 1.49 | 1.16, 1.90 | 0.002* | 1.63 | 1.26, 2.11 | <0.001* | 1.32 | 1.08, 1.60 | 0.006* |
| Clinical tumor stage (ref: cTa/cTis/cT1) | |||||||||
| cT2 | 1.71 | 1.35, 2.15 | <0.001* | 1.84 | 1.44, 2.36 | <0.001* | 1.66 | 1.38, 1.98 | <0.001* |
| cT3/cT4 | 1.97 | 1.31, 2.96 | 0.001* | 2.21 | 1.45, 3.38 | <0.001* | 1.85 | 1.34, 2.54 | <0.001* |
| C‐Index of the full model (all variables included) | 65.4 (SE = 0.016) | 68.1 (SE = 0.016) | 65.9 (SE = 0.013) | ||||||
| C‐Index of the model without biomarkers levels (reference model) | 60.5 (SE = 0.016) | 63.2 (SE = 0.016) | 63.6 (SE = 0.013) | ||||||
| Additive value of the biomarkers in % | 4.9% | 4.9% | 2.3% | ||||||
*
Statistically significant value.