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. 2022 Sep 27;18(9):e1010430. doi: 10.1371/journal.pgen.1010430

Fig 5. Glucose and fructose metabolism differences between the DPAGT1 and ER stress models.

Fig 5

(A-B) In the ER stress model, knockdown of PFKM/Pfk (BDSC 34336) and PFKFB1/Pfrx (BDSC 57222) causes a worsening of eye size compared to control RNAi (attP2, BDSC 36303; and attP40, BDSC 36304). In contrast, in the DPAGT1 model, knockdown of these genes causes an overall improvement of eye size. (C) 100mM dietary glucose or fructose significantly reduced eye size in the ER stress model. Wild type refers to the genetically-matched background strain. (D) Compared to its background control, feeding of 100mM glucose or fructose was net-positive in the DPAGT1 model. Wild type refers to the genetically-matched background strain. For A-D, 1 replicate is shown of 2 biological replicates (S8 Table), * p< 0.05, ** p<0.01, *** p<0.001 (Student’s t test).