Table 5. Genetic ontology (GO) of biologic process and function and KEGG and REACTOME data banks pathway analysis associated to the seventeen target genes related to at least two miRNAs.
| Biologic Processes | p-value | Molecular Functions | p-value |
| Intrinsic apoptotic signaling pathway in response to damage by p53 class mediator | 4.2x10-6 | Protein tyrosine/serine/threonine phosphatase activity | 1.7x10-4 |
| Epidermal growth factor receptor signaling pathway | 1.6x10-4 | SMAD binding | 1.9x10-3 |
| Positive regulation of fat cell differentiation | 5.4x10-4 | Protein serine/threonine kinase activity | 2.8x10-3 |
| Non-canonical Wnt signaling pathway | 1.3x10-3 | TGF-β binding | 5.1x10-3 |
| Cellular response to TGF-β stimulus | 1.5x10-3 | Neuropeptide hormone activity | 5.5x10-3 |
| Regulation of apoptotic process | 2.5x10-3 | Protein tyrosine kinase activity | 8.6x10-3 |
| Pathway-restricted SMAD protein phosphorylation | 4.6x10-3 | Protein serine/threonine/tyrosine kinase activity | 0.01 |
| TGF-β signaling pathway | 7.3x10-3 | G-protein coupled receptor activity | 0.02 |
| Retinoic acid metabolic process | 8.1x10-3 | Phosphatidylinositol-3-phosphatase activity | 0.03 |
| Regulation of cyclin-dependent protein serine/threonine kinase activity | 0.01 | Wnt-activated receptor activity | 0.03 |
| Positive regulation of inflammatory response | 0.01 | Phosphatidylinositol 3-kinase binding | 0.03 |
| Activation of MAPK activity | 0.02 | ||
| Positive regulation of angiogenesis | 0.02 | ||
| VEGF signaling pathway | 0.02 | ||
| KEGG Pathways | p-value | REACTOME Pathways | p-value |
| Insulin signaling pathway | 5.5x10-4 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | 1.7x10-5 |
| Steroid hormone biosynthesis | 2.2x10-3 | Signaling TGF-β Family members | 4.1x10-5 |
| Erbb signaling pathway | 3.6x10-3 | Signaling by receptor tyrosine kinases | 2.0x10-4 |
| Retinol metabolism | 3.9x10-3 | Signaling by VEGF | 1.9x10-3 |
| MAPK signaling pathway | 5.7x10-3 | MAP2K and MAPK activation | 2.9x10-3 |
| Inositol phosphate metabolism | 6.2x10-3 | Negative regulation of MAPK pathway | 0.01 |
| TGF-β signaling pathway | 9.6x10-3 | TGF-β receptor signaling activates SMADs | 0.02 |
| Adipocytokine signaling pathway | 0.03 | Insulin receptor recycling | 0.04 |
Biologic Process and Functions and Pathways described were selected based on their potential to be related to PCOS physiopathology.