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. 2022 Jan 17;112(2):279–288. doi: 10.1002/JLB.3AB1220-846R

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© 2022 The Authors. Journal of Leukocyte Biology published by Wiley Periodicals LLC on behalf of Society for Leukocyte Biology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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SNPs around the steroidogenesis genes correlate with cytokine production after ex vivo training with oxLDL. (A) Heatmap highlighting SNPs in the steroidogenesis pathways that correlate with levels of TNFα and IL‐6 following ex vivo training with oxLDL (10 μg/ml) and restimulation with LPS (10 ng/ml). The color legend for the heatmap indicates the range of p values from QTL mapping. (B) Boxplots showing the genotype‐stratified cytokine levels for the most strongly correlated SNPS in the PGR, GR, NR3C2, and ESR loci for TNFα and IL‐6, respectively (n = 215 healthy volunteers for TNFα, n = 228 healthy volunteers for IL‐6)