Skip to main content
. 2022 Jun 28;72(8):402–410. doi: 10.1111/pin.13255

Figure 1.

Figure 1

Pattern of paired‐like homeobox 2b (PHOX2B) expression usually differentiates metastases of peripheral neuroblastoma from central nervous system tumors with embryonal morphology, but focal elevated percent positivity is present in some embryonal tumors with multilayered rosettes (ETMR). (a–c) Case 38, peripheral neuroblastoma metastatic to the brain (a: hematoxylin and eosin (H&E) of area with neurocytic and ganglion cell differentiation, 100× magnification; b: PHOX2B showing a diffuse pattern of immunoreactivity, 100× magnification; c: PHOX2B, 400× magnification). (d–f) Case 7, embryonal tumor with multilayered rosettes (d: H&E of neuropil‐rich area with neuronal differentiation, 100× magnification; e: PHOX2B showing scattered small aggregates of positive cells, 100× magnification; f: PHOX2B, 400× magnification).