TABLE 3.
Laboratory values at time of diagnosis (non‐deceased iMCD, n = 66 and deceased iMCD cohorts, n = 6)
| iMCD group | Non‐deceased iMCD | Deceased iMCD |
p value |
||||
|---|---|---|---|---|---|---|---|
| Laboratory measures | Mean | SD | n | Mean | SD | n | |
| Haematology | |||||||
| Absolute basophil count (×109/l) | 0.24 | 1.60 | 65 | 0.06 | 0.08 | 5 | 0.3851 |
| Absolute eosinophil count (×109/l) | 0.14 | 0.15 | 65 | 0.10 | 0.15 | 5 | 0.6791 |
| Absolute lymphocyte count (×109/l) | 2.23 | 3.02 | 65 | 1.61 | 0.66 | 5 | 0.2265 |
| Absolute monocyte count (×109/l) | 2.78 | 16.00 | 65 | 1.28 | 0.96 | 5 | 0.4671 |
| Absolute neutrophil count (×109/l) | 7.18 | 3.85 | 66 | 6.65 | 3.86 | 6 | 0.7810 |
| Haemoglobin (g/l) a | 104.8 | 25.1 | 66 | 85.0 | 28.4 | 6 | 0.1843 |
| International normalised ratio | 1.70 | 2.09 | 63 | 1.13 | 0.14 | 6 | 0.0427 |
| Platelet count (×109/l) | 217.97 | 166.80 | 66 | 92.67 | 76.17 | 6 | 0.0114 |
| Prothrombin time | 14.16 | 2.94 | 55 | 14.40 | 2.78 | 6 | 0.8612 |
| White blood cell count (×109/l) | 10.18 | 3.83 | 65 | 12.89 | 10.65 | 6 | 0.5944 |
| Chemistry | |||||||
| Albumin (g/dl) a | 31.4 | 14.8 | 66 | 28.8 | 0.99 | 6 | 0.6113 |
| Alkaline phosphatase (μkat/l) | 2.32 | 1.61 | 66 | 2.47 | 1.14 | 6 | 0.7898 |
| Alanine aminotransferase (μkat/l) | 0.35 | 0.30 | 66 | 0.51 | 0.38 | 6 | 0.3828 |
| Aspartate aminotransferase (μkat/l) | 0.39 | 0.25 | 66 | 0.50 | 0.19 | 6 | 0.2912 |
| Blood urea nitrogen (mmol/l) | 0.89 | 6.24 | 66 | 10.21 | 4.74 | 5 | 0.4231 |
| Creatinine (μmol/l) | 248.40 | 1155.39 | 66 | 91.94 | 20.33 | 6 | 0.2816 |
| C‐reactive protein (mg/l) a | 76.83 | 88.18 | 61 | 138.54 | 88.42 | 6 | 0.1855 |
| Estimated glomerular filtration (rate ml/min/1.73m2) | 1.63 | 0.48 | 60 | 1.20 | 0.40 | 5 | 0.0956 |
| Lactate dehydrogenase (μkat/l) | 4.20 | 3.14 | 64 | 8.65 | 9.52 | 6 | 0.3450 |
| Total bilirubin (μmol/l) | 20.87 | 31.3 | 65 | 33.69 | 52.51 | 6 | 0.6149 |
| Uric acid (mmol/l) | 0.40 | 0.18 | 53 | 0.34 | 0.13 | 5 | 0.4357 |
| Immunology | |||||||
| Immunoglobulin A (g/l) | 2.46 | 1.71 | 58 | 1.40 | 0.78 | 4 | 0.0934 |
| Immunoglobulin G (g/l) | 18.76 | 16.11 | 61 | 15.67 | 9.27 | 6 | 0.5246 |
| Immunoglobulin M (g/l) | 1.09 | 0.77 | 60 | 0.46 | 0.18 | 5 | 0.0002 |
p values in bold denote significance. iMCD, idiopathic multicentric Castleman disease; SD, standard deviation.
a
Patients were matched in part based on C‐reactive protein, haemoglobin and albumin (CHA), so the results of these differences in CHA would not be expected to be different.