Table 5.
Articles about the comparison of re-positioning maneuvers (Epley or Semont) and the medication only.
| Study | Type of BPPV |
Treatment | Follow-up protocol | Control | Outcome |
|---|---|---|---|---|---|
| Itaya et al, 199745 | PC | Epley (15) v Semont (14) and drug alone (26); (vit B12, Diazepam Betahistine, Antivert) | DHT | Control at 3, 7 and 14 days | Epley %93.3, Semont 78.6%, Medication only 30.8% |
| Salvinelli et al, 200446 | PC | Semont (52) v Flunarizine (52) and no treatment (52) | Negative DHT and Vertigo questionnaire | 1 week intervals upto 6 months | Success; Semont 85%, Flunarizine 57.7%, no treatment 34.6% |
| Sundararajan et al, 201147 | PC | Epley (25) v Epley + Cinnerazine (26) | DHT and self-rated evaluation | Control at 1 and 4 weeks | Complete cure at 4 weeks; Epley 84% Epley + drug 57% |
| Guneri et al, 201248 | PC | Epley (22) v Epley + placebo (26) and Epley + Betahistine (24) | DHI, VDADLS, EEV, VSS and DHT | Control at 2 weeks | Success; No difference 86.9%, 84.7%, 97.5% |
| Jung et al, 201251 | All types | Medication (etizolam) (39) v no treatment (34) | RD after successful maneuver; SVV, DHI and ABC | 2 weeks | No significant difference between groups in DHI, ABC scores and SVV tilting |
| Maslovara et al, 201255 | PC | Epley (45) v Betahistine (46) | Symptom resolution DHT and DHI | 1 and 8 weeks | Resolution at 1st week Epley 93.3%, Medication 86.9% |
| Otsuka et al, 201349 | PC-LC | Epley (194), Lempert (31) Betahistine (38) | DHT, Roll-on test | Follow-up 1-6 years | Resolution time is significantly shorter for maneuver groups. |
| Kim et al, 201453 | PC-LC | Dimenhydrinate (45) v placebo (46) and no treatment (47) | Improvement in RD after successful Epley; DHI | 1 week | Success; vestibular suppressant 67%, Placebo 47% and no treatment 43% |
| Sacco et al. 201444 | PC | Epley (15) v Medication, (Diazem, antiemetic, antihistaminic) (11) | Symptom resolution DHI and phone follow-up | 2 hours at ER and phone-call at 30 days | No significant difference |
| Kaur et al, 201750 | PC | Epley (30) v Epley + Betahistine (30) and Betahistine alone (30) | Symptom resolution and recurrence DHI, VAS and DHT | 4 weeks follow-up | Significant Epley + Betahistine 94.8%, Betahistine 87.1% |
| Casani et al, 201954 | PC | Epley (131) v Epley + Polyphenol compound suppl (127) | Improvement in RD after successful Epley; DHI, VAS, SP and DHT | Control at 1st and 2nd month | Efficacy at 1st and 2nd month Polyphenol 81% and 91% No drug 90% |
| Jalali et al, 202052 | PC | Betahistine (39) Dimenhydrinate (39) Placebo (39) | Improvement in RD after successful Epley; DHI and BBS | 1 week | Betahistine; 58.6% Dimenhydrinate; 44.8% Placebo; 26.7% |
Abbreviations: BPPV, Benign paroxysmal positional vertigo; PC, posterior canal; LC, lateral canal; DHT, Dix-Hallpike test; VSS, visual symptom scale; DHI, dizziness handicap inventory; SVV, subjective visual vertical RD residual dizziness SP Static posturography; ER; Emergency room; BBS, Berg balance scale; EEV, European evaluation of vertigo; ABC, Activities-specific balance confidence; VDADLS, Vestibular disorders activities daily living scale