Skip to main content
. 2022 Jun 13;92(2):213–229. doi: 10.1002/ana.26409

FIGURE 5.

FIGURE 5

Evolution of the emotional response over time after intracerebroventricular (ICV) injection tricyclo‐DNA antisense oligonucleotide (tcDNA‐ASO). (A‐C) Behavioral parameters recorded during 5 minutes after a mild stress induced by a short (15 seconds) manual restraint in wild‐type (WT) and mdx mice treated with phosphate‐buffered saline (PBS) or 400 μg of tcDNA‐ASO 4, 5, 6, 7, and 10 weeks after the ICV treatment. (A) Restraint‐induced unconditioned fear responses expressed as the percentage of time spent freezing. (B) Horizontal activity expressed as the total distance travelled (m). (C) vertical activity expressed as the number of rearings. Results are expressed as means ± SEM; n = 7 (4 weeks), 6 (5 weeks), 6 (6 weeks), 4 (7 weeks), and 3 (10 weeks) per tcDNA‐treated group with 400 μg, n = 4 for mdx PBS control and n = 7 (4 weeks), 6 (5 weeks), 6 (6 weeks), 4 (7 weeks), and 3 (10 weeks) for WT. *p < 0.05 compared with mdx controls, ### p < 0.001 and # p < 0.05 compared with WT (ANOVA).