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. 2022 Jun 7;29(8):2420–2430. doi: 10.1111/ene.15382

FIGURE 4.

FIGURE 4

A predictor, based on miR‐133a‐3p and miR‐206, predicts response to nusinersen. (a–e) Receiver operating characteristic curves with leave‐one‐out cross‐validation (LOOCV) for (a) miR‐133a‐3p + miR‐206, (b) miR‐133a‐3p + miR‐206 + spinal muscular atrophy (SMA) type, (c) miR‐133a‐3p + miR‐206 + SMA type + sex, (d) miR‐133a‐3p + miR‐206 + baseline Hammersmith Functional Motor Scale Expanded (HFMSE) score, and (e) miR‐133a‐3p + miR‐206 + baseline HFMSE score + sex. (f) A summary of logistic regression metrics for five multiple feature models. AIC, Akaike information criterion; AUC, area under the curve. For the sake of brevity, miR‐133a‐3p is referred to in this figure and the next figure as "miR‐133a" [Colour figure can be viewed at wileyonlinelibrary.com]