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. 2022 Jun 7;29(8):2420–2430. doi: 10.1111/ene.15382

FIGURE 5.

FIGURE 5

A predictor, based on a summation of the scaled values of miR‐133a and miR‐206, predicts response to nusinersen. (a) Logistic regression analysis of miR‐133a/206 at baseline and clinical response to therapy after 6 months of nusinersen treatment. When the extreme sample whose miR‐133a/206 score was 2 is excluded, chi‐squared slightly decreases (from 9 to 8) and the p‐value marginally increases (from 0.003 to 0.0046), suggesting the overall data and interpretation remain unchanged. (b–d) Receiver operating characteristic curves based on leave‐one‐out cross‐validation (LOOCV) for (b) miR‐133a/206, (c) miR‐133a/206 with spinal muscular atrophy (SMA) type and sex, and (d) miR‐133a/206 with baseline Hammersmith Functional Motor Scale Expanded (HFMSE) and sex. (e) A summary of logistic regression metrics for three models. AIC, Akaike information criterion; AUC, area under the curve [Colour figure can be viewed at wileyonlinelibrary.com]