FIGURE 5.

Interaction between SERT deletion and cocaine self‐administration (short or long access) on the scaffolding proteins SAP102 and SAP97 in the core nucleus accumbens. Protein levels of SAP102 (a) and SAP97 (b) are expressed as percentages of SERT^+/+‐naive rats. Below the graphs, representative immunoblots are shown for SAP102 (102 kDa), SAP97 (97 kDa) and β‐actin (43 kDa) proteins. Histograms represent the mean ± SEM of the following number of rats: naïve (SERT^+/+ n = 7; SERT^−/− n = 7), short access (SERT^+/+ n = 6; SERT^−/− n = 6) and long access (SERT^+/+ n = 7; SERT^−/− n = 7). *P < .05 versus SERT^+/+‐naive; ^# P < .05 versus SERT^+/+‐short access; ^£ P < .05 versus SERT^−/−‐naïve; °P < .05 versus SERT^−/−‐short access (Tukey's multiple comparisons test). N, naïve; S, Cocaine Short‐Access; L, Cocaine Long‐Access