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. 2022 Jun 1;76(8):367–376. doi: 10.1111/pcn.13373

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© 2022 The Authors. Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Fig. 4 — Relationship between plasma kynurenine (KYN) levels and left dorsolateral prefrontal cortex (DLPFC) activity at baseline (T1). (a) The mean fractional amplitude of low‐frequency fluctuation (fALFF) values of the left DLPFC region of interest (ROI) was correlated with plasma KYN levels in patients with major depressive disorder. (b) Mean fALFF values of the left DLPFC ROI were also correlated with plasma KYN levels in healthy control (HC) subjects.