TABLE 2.
Baseline characteristics
| Characteristics | Period | p‐value | |
|---|---|---|---|
| qFFP | SDP | ||
| ICU admissions, n | 4563 | 4381 | |
| Age, years | 65 (54 to 74) | 65 (54 to 73) | 0.655 |
| Male, n (%) | 2896 (63.5%) | 2855 (65.2%) | 0.085 |
| BMI | 26.4 ± 5.0 | 26.5 ± 5.1 | 0.184 |
| APACHE‐II Score | 15 (12 to 21) | 15 (12 to 21) | 0.396 |
| SAPS | 33 (25 to 45) | 33 (26 to 46) | 0.081 |
| Products transfused, n | 5985 | 6819 | <0.001 |
| RBC units | 3694 | 3765 | 0.160 |
| PLTs units | 1023 | 1141 | 0.011 |
| Plasma products | 1171 | 2008 | < 0.001 |
| qFFP | 1171 | 0 | “ |
| SDP | 0 | 2008 | “ |
| Plasma units (vol. corrected) a | 1171 | 1294 | 0.013 |
| Patients transfused, n (%) | 1068 (23.4) | 1000 (22.8) | 0.516 |
| Units per patient transfused | 3 (1 to 6) | 3 (1 to 6) | 0.269 |
| RBC units | 2 (1 to 4) | 2 (1 to 5) | 0.742 |
| PLT units | 1 (1 to 2) | 1 (1 to 2) | 0.057 |
| Plasma units | 2 (1 to 4) | 2 (1 to 4) | 0.255 |
| Plasma volume (L/patient) † | 1.2 (0.6 to 3.1) | 1.2 (0.6 to 5.0) | < 0.001 |
| Type of admission, n (%) | < 0.001 | ||
| Medical | 1666 (36.5%) | 1664 (38.0%) | |
| Emergency surgery | 762 (16.7%) | 832 (19.0%) | |
| Planned surgery | 2130 (46.7%) | 1885 (43.0%) | |
| Comorbidities, n (%) | |||
| Chronic renal disease | 279 (6.1) | 244 (5.6) | 0.272 |
| COPD | 359 (7.9%) | 355 (8.1%) | 0.698 |
| Hematological malignancy | 104 (2.3%) | 109 (2.5%) | 0.521 |
| Immunological insufficiency | 316 (6.9%) | 358 (8.2%) | 0.032 |
| Diabetes | 749 (16.4%) | 720 (16.4%) | 1.000 |
| History of heart failure | 356 (7.8%) | 273 (6.2%) | 0.006 |
| Cirrhosis | 83 (1.8%) | 57 (1.3%) | 0.044 |
| Risk factors, n (%) | |||
| Direct | |||
| Pneumonia | 133 (2.9%) | 129 (2.9%) | 0.954 |
| Aspiration | 35 (0.8%) | 27 (0.6%) | 0.461 |
| Inhalation: smoke/drowning | 7 (0.2%) | 3 (0.1%) | 0.352 |
| Indirect | |||
| Sepsis | 187 (4.1%) | 190 (4.3%) | 0.596 |
| Trauma | 182 (4.0%) | 176 (4.0%) | 0.951 |
| Pancreatitis | 8 (0.2%) | 11 (0.3%) | 0.496 |
| Drug overdose | 87 (1.9%) | 97 (2.2%) | 0.325 |
| Other | |||
| Cardiac surgery | 1702 (37.3%) | 1621 (37.0%) | 0.767 |
| CVA | 195 (4.3%) | 187 (4.3%) | 1.000 |
| Cardiac arrest | 216 (4.7%) | 212 (4.8%) | 0.842 |
| Hospital LOS (days) | 9 (5 to 18) | 10 (6 to 26) | 0.000 |
| ICU LOS (days) | 2 (1 to 3) | 2 (1 to 3) | 0.026 |
| Died in ICU, n (%) | 437 (9.6%) | 421 (9.6%) | 0.972 |
Note: Data presented as mean ± SD or median (IQR).
a
Calculated plasma volume transfused per patient.
†
The number of SDP units transfused when correcting for volume (qFFP 310 mL vs. SDP 200 mL).
Abbreviations: ALI, acute lung injury; COPD, chronic obstructive pulmonary disease; CVA, cerebrovascular accident; LOS, length of stay; PLT, platelet transfusion; qFFP, quarantine single unit fresh frozen plasma; RBC, red blood cells; SAPS, simplified acute physiology score; SDP, solvent/detergent treated pooled plasma.