TABLE 3.
TRALI patient characteristics
| Characteristics | Period | p‐value | |
|---|---|---|---|
| qFFP | SDP | ||
| TRALI patients (n) | 10 | 9 | |
| Type I | 4 (40%) | 2 (22%) | 0.405 |
| Type II | 6 (60%) | 7 (78%) | “ |
| Age (years) | 67 (65 to 73) | 62 (41 to 72) | 0.225 |
| Male (n, %) | 4 (40%) | 6 (67%) | 0.365 |
| BMI | 24.2 ± 3.9 | 25.2 ± 3.0 | 0.519 |
| Apache‐II score | 25 (21 to 27) | 23 (21 to 32) | 0.485 |
| SAPS | 51 (41 to 61) | 54 (52 to 79) | 0.253 |
| Transfusion data (n, %) | 0.930 | ||
| Plasma only | 2 (20%) | 1 (11%) | |
| Addition RBC units | 6 (60%) | 5 (56%) | |
| Addition PLT units | 7 (70%) | 5 (56%) | |
| Imputability (n, %) | 0.084 | ||
| Definite | 2 (20%) | 0 (0%) | |
| Possible | 2 (20%) | 6 (67%) | |
| Probable | 6 (60%) | 3 (33%) | |
| Diagnosis (n, %) | 0.081 | ||
| Cardiac arrest | 2 (20%) | 1 (11%) | |
| Major thoracic surgery | 2 (20%) | 1 (11%) | |
| Acute abdominal aortic dissection | 1 (10%) | 1 (10%) | |
| Pneumosepsis | 0 (0%) | 2 (22%) | |
| Sepsis (other) | 2 (20%) | 0 (0%) | |
| Pancreatitis | 0 (0%) | 2 (22%) | |
| Massive hemorrhage | 3 (30%) | 0 (0%) | |
| Other | 0 (0%) | 3 (33%) | |
| Presentation | |||
| P/F‐ratio pre‐transfusion | 245 (205 to 306) | 216 (171 to 339) | 0.897 |
| P/F‐ratio post‐transfusion | 192 (158 to 243) | 207 (164 to 365) | 0.447 |
| ΔStatic compliance (mL/cmH2O) a | −6.7 (−23 to −0.3) | −7.5 (−14 to −2.5) | 1.000 |
| Chest X‐ray (n, bilateral infiltrates (%)) | 10 (100%) | 9 (100%) | 1.000 |
| ΔLeukocytes | −0.5 (−6.8 to 3.6) | 3.2 (2.5 to 8.3) | 0.194 |
| ΔTemperature (°C) | −0.0 (−0.8 to 0.5) | −0.2 (−0.7 to 0.3) | 0.870 |
| Fluid balance, past 72 hrs (L) | 4.1 (2.9 to 8.2) | 6.0 (2.6 to 9.9) | 0.807 |
| Echocardiography (n), impaired (%) † | 8 (20%) | 6 (33%) | 0.276 |
| Outcomes | |||
| Hospital LOS (days) | 11 (6 to 22) | 14 (3 to 27) | 1.000 |
| ICU LOS (days) | 5 (4 to 10) | 11 (3 to 28) | 0.253 |
| Died in ICU (n, %) | 7 (70%) | 6 (67%) | 1.000 |
Note: Data presented as mean ± SD or median (IQR).
Abbreviations: LOS, length of stay; P/F‐ratio, PaO2‐FiO2‐ratio; PLT, platelet transfusion; qFFP, quarantined fresh frozen plasma; RBC, red blood cells; SAPS, simplified acute physiology score; SDP, solvent/detergent treated pooled plasma.
a
Static compliance: calculated as tidal volume (mL)/driving pressure (cmH2O).
†
Shown as number of patients with a recent echocardiogram performed and percentage of patients with an impaired LV‐function (moderate or worse).