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. 2022 Apr 11;100(5):352–370. doi: 10.1111/imcb.12547

Figure 2.

Figure 2

Pseudomonas aeruginosa elicits proinflammatory epithelial signals. Heat maps show median‐fold change (FC) of cytokine concentrations in washes of infected air–liquid interface cultures over washes of uninfected cultures. (a) Cytokines with > 5 FC. (b) Cytokines with ≤ 5 FC. (c) IP‐10, (d) MIG and (e) RANTES increased in response to exclusive rhinovirus (RV) infection and (f) IL‐1α, (g) IL‐1β and (h) IL‐1Ra increased in response to P. aeruginosa and viral–bacterial co‐infection [*P < 0.05, **P < 0.01, ***P < 0.001 compared with uninfected controls, repeated measures (RM) one‐way ANOVA]. Error bars indicate mean ± standard deviation. Data points indicate cytokine concentrations in washes of individual primary cell cultures. CF, cystic fibrosis; IL, interferon gamma‐induced protein 10; interleukin; IP‐10, MIG, monokine induced by gamma interferon; Pa, Pseudomonas aeruginosa; RANTES, regulated on activation, normal T cell expressed and secreted.