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. 2022 Apr 11;100(5):352–370. doi: 10.1111/imcb.12547

Figure 6.

Figure 6

Anti‐GRIM drug screen. Median fluorescence intensity of stains for neutrophil functional markers (a) CD16, (b) CD63 and (c) CD66b in neutrophils following migration into rhinovirus (RV) + Pseudomonas aeruginosa air–liquid interface washes with added compounds [*P < 0.05, **P < 0.01, ***P < 0.001 compared with nonmigrated neutrophils, repeated measures (RM) one‐way ANOVA]. (d) Total migrated neutrophils, (e) % A1 (baseline) subset and (f) % A2 (GRIM) subset of neutrophils for each condition (*P < 0.05, **P < 0.01, ***P < 0.001 compared with uninfected controls, RM one‐way ANOVA). Error bars indicate mean ± standard deviation. Data points indicate neutrophil responses from six individual neutrophil donors. GRIM, granule‐releasing, immunoregulatory and metabolically active phenotype.