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. 2022 May 6;237(7):3001–3011. doi: 10.1002/jcp.30756

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© 2022 The Authors. Journal of Cellular Physiology published by Wiley Periodicals LLC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Upregulation of MEK/ERK signaling pathway activates inflamed Crohn's mesentery macrophage activation and migration. (A) Upstream regulation of differentially expressed genes by MEK/ERK on the activation of macrophages in CD SubQ versus CD Mes comparison. Grey, expressed; Red, upregulated; Orange, activated. (B) Upstream regulation of differentially expressed genes by MEK/ERK on the migration of macrophages in CD SubQ versus CD Mes comparison. Grey, expressed; Red, upregulated; Orange, activated. (C) Western blot analysis of CD patients' noninflamed and inflamed mesentery for ERK, MEK, and Actin. (D) Densitometry of ERK and MEK normalized to actin and the matching noninflamed tissue. CD, Crohn's disease.