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. 2022 Jun 23;53(5):640–656. doi: 10.1111/age.13233

FIGURE 2.

FIGURE 2

Location of missense SNPs with regards to predicted protein domains. (a) IFNAR1 – Y217, E219G and A404V can be found in fibronectin type 3 (FN3) domains. (b) IFNAR2 – P45S occurs in a tissue factor domain, N188D and I214T occur in an interferon binding domain and G264V occurs in the transmembrane region. (c) IFNGR1 – no SNPs were identified in the predicted domains. (d) IFNGR2 – C44R in tissue factor domain. (e) IFNLR1 – E151G, S199P and S211P occur in an interferon binding domain. (f) IL10Rβ – no SNPs were identified in predicted domains. (g) IFNβ – S151P SNP occurs in an IFNα/β/δ domain. (h) STAT1 – V341G SNP occurs in a STAT binding domain. (i) JAK1 – Y500D occurs in an Src Homolog 2 (SH2) domain. (j) TYK2 – H215P and R299Q occur in a band 4.1 (B41) domain and S875N, S883P and D908A occur in tyrosine kinase catalytic domains (TyrKc). (k) IRF9 – Y335S occurs in an interferon regulatory factor 3 (IRF3) domain. Note, chickens lack IRF3 but have an IRF7 orthologue. IFαβδ, Interferon alpha, beta and delta domain; STAT_int, STAT protein interaction domain; STAT_alpha, STAT protein all‐alpha domain; STAT_bind, STAT protein DNA binding domain; B41, band 4.1 homologue domain (also known as ERM domain, erzin/radixin/moesin domain); STYKc, protein kinase of unclassified specificity; IRF, interferon regulatory factor domain. Pink indicates low complexity regions and dark blue blocks signify transmembrane regions