TABLE 1.
Clinical features at the time of transplant of DCD and DBD LT recipients in the United States stratified by UW versus HTK, 2006–2020
| Variables | DCD a | DBD a | ||
|---|---|---|---|---|
| UW (n = 3873) | HTK (n = 1944) | UW (n = 63,511) | HTK (n = 15,855) | |
| Donor | ||||
| Age, years | 34.0 (24.0–46.0) | 36.0 (24.0–47.0)** | 43.0 (28.0–55.0) | 43.0 (29.0–55.0)** |
| BMI, kg/m2 | 26.1 (22.8–30.2) | 26.1 (22.8–30.5) | 26.7 (23.4–31.0) | 27.0 (23.5–31.5)*** |
| Male sex | 2646 (68.3) | 1300 (66.9) | 37,999 (59.8) | 9324 (58.8)* |
| White race | 3029 (78.2) | 1589 (81.7)** | 39,287 (61.9) | 11,313 (71.4)*** |
| HCV | 125 (3.2) | 88 (4.5)* | 3841 (6.0) | 1172 (7.4)*** |
| ECD | 228 (5.9) | 121 (6.2) | 16,709 (26.3) | 4133 (26.1) |
| CIT, h | 5.7 (4.7–7.0) | 5.3 (4.3–6.9)*** | 6.1 (4.9–7.8) | 5.9 (4.5–7.3)*** |
| Recipient | ||||
| Age, years | 58.0 (52.0–63.0) | 58.0 (52.0–63.0) | 57.0 (50.0–63.0) | 57.0 (50.0–62.0)** |
| Male sex | 2670 (68.9) | 1314 (67.6) | 42,060 (66.2) | 10,710 (67.5)** |
| White race | 2816 (72.7) | 1500 (77.2)*** | 43,718 (68.8) | 11,941 (75.3)*** |
| BMI, kg/m2 | 27.9 (24.5–32.1) | 28.2 (24.8–32.5) | 28.0 (24.5–32.3) | 28.2 (24.6–32.4)* |
| Posttransplant LOS, days | 9.0 (6.0–15.0) | 9.0 (7.0–15.0)** | 10.0 (7.0–17.0) | 10.0 (7.0–16.0) |
| Waiting list time, days | 113.0 (29.0–294.0) | 101.0 (29.5–277.0) | 84.0 (14.0–287.0) | 86.0 (17.0–258.0) |
| Diabetes mellitus | 1168 (30.2) | 11 (14.9)* | 17,305 (27.2) | 4257 (26.8) |
| MELD score | 18.0 (13.0–24.0) | 18.0 (13.0–24.0) | 22.0 (14.0–32.0) | 21.0 (14.0–29.0)*** |
| Life support requirement | 166 (4.3) | 53 (2.7) | 5730 (9.0) | 865 (5.5)*** |
| ICU | 217 (5.6) | 86 (4.4) | 9581 (15.1) | 1610 (10.2)*** |
| Dialysis requirement | 314 (8.1) | 131 (6.7) | 10,124 (15.9) | 2000 (12.6)*** |
| Ascites, mild or worse | 2789 (72.0) | 1484 (76.3)*** | 47,183 (74.3) | 12,420 (78.3)*** |
| Hepatic encephalopathy, grade 1 or worse | 2406 (62.1) | 1257 (64.7) | 39,688 (62.5) | 10,691 (67.4)*** |
| PVT | 447 (11.5) | 239 (12.3) | 7380 (11.6) | 1796 (11.3) |
| HCC | 1330 (34.3) | 637 (32.8) | 18,773 (29.6) | 4666 (29.4) |
| SLKT | 279 (7.2) | 110 (5.7)* | 5256 (8.3) | 1293 (8.2) |
Values are n (%) or median (interquartile range).
Abbreviations: BMI, body mass index; CIT, cold ischemia time; DBD, donation after brain death; DCD, donation after circulatory death; ECD, expanded criteria donor; HCV, hepatitis C virus; HTK, histidine‐tryptophan‐ketoglutarate solution; ICU, intensive care unit; LOS, length of stay; LT, liver transplantation; MELD, Model for End‐Stage Liver Disease; PVT, portal vein thrombosis; SLKT, simultaneous liver–kidney transplantation; UW, University of Wisconsin solution.
The UW and HTK groups are compared with each other within respective deceased donor categories (DCD or DBD) by pairwise comparisons via the chi‐square test for categorical variables and the two‐sample Wilcoxon rank test for continuous variables (all continuous variables failed the Shapiro–Wilk normality test). The variables contained <1% of missing data: missing values of continuous variables were ignored, whereas missing values of categorical variables were assumed to be negative.
p < 0.001
0.001 < p ≤ 0.01
0.01 < p ≤ 0.05 (all other p values > 0.05).