FIGURE 5.

Three‐dimensional model structure of the PPA/α–AI1 complex. One monomer unit of α‐AI1 (template 1dhk.1.B) in interaction with a molecule of PPA (template 3l2l.1.A) is shown. The two hairpin loops (L1 and L2) of α‐AI1 interacting directly with the active site of PPA are highlighted. The α‐AI1 tyrosine, aspartate, and serine sidechains (Y37, Y186, Y190, D38, S189), important to the interaction with catalytically important residues of PPA enzyme (E233, D197, D300, H201, N298) are reported with the one‐letter code. The * indicate the three amino acids of α‐AI1 directly involved in the catalytic mechanism. The 3D structures were generated using SWISS‐MODEL (http://swissmodel.expasy.org) server. α‐AI, α‐amylase inhibitor; PPA, porcine pancreatic α‐amylase