TABLE 1.
Main studies on animal models to test the efficacy of Phaseolus vulgaris extract
| Reference | Administration | Subjects | Side effects | Main results |
|---|---|---|---|---|
| Grant et al. (1995) | Raw beans | Healthy rats | Transitory pancreatic enlargement | Reduction in body lipid level |
| Pusztai et al. (1995) | Partially purified extract | Healthy rats | Intestinal blockage (cecum level) by solidified digesta | Weight loss |
| Fantini et al. (2009) | Dry extract | Healthy rats | No side effects | Reduction in rat body weight, glycemia and a decrease in food intake |
| Tormo et al. (2006) | Purified extract | Healthy and diabetic rats | No side effects | Reduction in glycemia and decrease in food intake in both group |
| Loi et al. (2013) | Partially purified extract | Healthy rats | Not available | Reduction in normal and palatable food intake ang glycemia |
| Tormo et al. (2004) | Purified extract | Healthy rats | No side effects | Anoressigenic effect, reduction in weight gain, and blood glucose level |
| Ocho‐Anin Atchibri et al. (2010) | P. vulgaris seeds + gilbenclamide | Diabetic rats | No side effects | Potent hypoglycemic and antihyperglycemic activity |
| Pereira et al. (2012) | Bean flour crude | Diabetic rats | No side effects | No change in physiological parameters, in biochemical marker and organ weight |
| Qin et al. (2019) | Aqueous extract | Healthy rats | No side effects | No significant weight loss, change in organ weight, food consumption, and blood biochemical parameters |