TABLE 2.
Outcome at age 7 years by etiology
| Intellectual disability | ASD | Cerebral palsy plus a | No NDV | Seizure‐free > 2 years b | Seizure‐ free and no NDV | |
|---|---|---|---|---|---|---|
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |
| Cerebral malformation, n = 16 | 13 (81) | 2 (12) | 11 (69) | 1 (6) | 3 (19) | 2 (12) |
|
Perinatal asphyxia, n = 10 |
8 (80) | 0(0) | 9(90) | 0(0) | 1(10) | 0(0) |
|
Metabolic disease, n = 10 |
10 (100) | 0(0) | 10(100) | 0(0) | 2(20) | 0(0) |
|
Tuberous sclerosis, n = 5 |
3 (60) | 3(60) | 0(0) | 0(0) | 1(20) | 0(0) |
|
Stroke, n = 5 |
3 (60) | 0(0) | 3(60) | 2(40) | 3(60) | 2(40) |
| Struct/Met/Inf etiology, n = 52 | 40 (77) | 5(10) | 36(69) | 6(12) | 13(25) | 6(12) |
| Genetic etiol, no s/m c , n = 17 | 12 (71) | 2(12) | 2(12) | 4(24) | 12(71) | 4(24) |
|
Unknown etiology, n = 47 |
5(11) | 6(13) | 0(0) | 32(68) | 36(77) | 30(64) |
Abbreviations: ASD, autism spectrum disorder. NDV = neurodevelopmental problem, includes intellectual disability, autism spectrum disorder, cerebral palsy, attention‐deficit/hyperactivity disorder, other learning difficulties, other motor impairments. Struct/Met/Inf etiology, includes structural, metabolic and infectious etiology.
a
“Cerebral palsy plus” includes 28 cases of cerebral palsy and 10 cases of similar motor symptoms in progressive metabolic disease.
b
Seizure‐free for 2 years or longer at age 7.
c
Molecularly confirmed genetic etiology without structural or metabolic abnormality.