Table 2.

Multivariable analysis for risk of major depressive disorder and IBD among probands and unaffected siblings

	Risk of depression			Risk of IBD
	Adjusted HR †	(95% CI)	P	Adjusted HR †	(95% CI)	P
Probands and their siblings
Unaffected siblings vs. control	1.82	1.14–2.91	0.013	1.69	1.05–2.69	0.029
Probands vs. control	9.43	6.43–13.81	< 0.001	1.87	1.07–3.26	0.028
Male sample
Unaffected siblings vs. control	1.67	0.77–3.63	0.199	1.47	0.81–2.66	0.206
Probands vs. control	14.43	8.16–25.51	< 0.001	2.17	1.07–4.38	0.032
Female sample
Unaffected siblings vs. control	1.87	1.02–3.40	0.042	2.17	1.00–4.70	0.050
Probands vs. control	6.92	4.08–11.74	< 0.001	1.61	0.65–3.97	0.306
Probands and younger siblings
Unaffected siblings vs. control	1.58	0.84–2.97	0.156	2.02	1.16–3.53	0.013
Probands vs. control	9.29	6.14–14.05	< 0.001	1.54	0.78–3.53	0.210
Probands and older siblings
Unaffected siblings vs. control	2.10	1.16–3.86	0.015	1.47	0.75–2.89	0.265
Probands vs. control	9.03	5.83–13.97	< 0.001	3.17	1.75–5.75	< 0.001
Sex, male vs. female	0.86	0.62–1.19	0.358	1.76	1.16–2.68	0.008
Charlson comorbidity index	1.19	1.08–1.30	< 0.001	1.31	1.15–1.50	< 0.001

^† Adjusted for age, sex, monthly income, urbanization, Charlson comorbidity index, medical comorbidities, and all‐cause clinical visits.

Bold indicates the statistical significance.

CI, confidence interval; HR, hazard ratio; IBD, inflammatory bowel disease.