Table 4.

Demographic data of probands with depression, unaffected siblings, and controls

	Depression probands (A), n = 25 552		Unaffected siblings (B), n = 26 147		Controls (C), n = 104 588		Pvalue	Post‐hoc
Age (years, SD)	26.23	8.49	19.43	9.55	19.46	9.57	< 0.001	A > B ~ C
Sex, n (%)							< 0.001
Male	9664	37.8	13 929	53.3	55 716	53.3
Female	15 888	62.2	12 218	46.7	48 872	46.7
Income (n, %)							< 0.001
≤ 15 840 NTD/month	10 101	39.5	10 120	38.7	40 480	38.7
15 841 ~ 25 000 NTD/month	8744	34.2	7668	29.3	30 672	29.3
≥ 25 001 NTD/month	6706	26.3	8359	32.0	33 436	32.0
Residence, n (%)							< 0.001
1 (urbanized)	6940	27.1	6923	26.5	27 692	26.5
2	8553	33.5	8834	33.8	35 336	33.8
3	3555	13.9	3503	13.4	14 012	13.4
4	2598	10.2	2457	9.4	9828	9.4
5 (rural)	3906	15.3	4430	16.9	17 720	16.9
Charlson comorbidity index	0.92	1.16	0.57	0.89	0.51	0.83	< 0.001	A > B > C
Medical comorbidities (n, %)
Hypertension	1098	4.3	605	2.3	2358	2.3	< 0.001	A > B ~ C
Dyslipidemia	1079	4.2	608	2.3	2281	2.2	< 0.001	A > B ~ C
Type 2 diabetes	521	2.0	343	1.3	1295	1.2	< 0.001	A > B ~ C
Obesity	754	3.0	401	1.5	1315	1.3	< 0.001	A > B > C
Smoking	1103	4.3	475	1.8	1457	1.4	< 0.001	A > B > C
IBD (n, per 1000)	18	0.70	25	0.96	58	0.55	0.068
UC	11	0.43	13	0.50	23	0.22	0.029	A ~ B > C
CD	7	0.27	12	0.46	35	0.33	0.499
Age at diagnosis (SD)	32.61	11.80	28.02	9.79	28.15	10.37	0.262
All‐cause clinical visits per year (SD)	8.52	7.45	4.81	4.83	4.77	10.16	< 0.001	A > B ~ C

CD, Crohn's disease; IBD, inflammatory bowel disease; NTD, New Taiwan Dollar; SD, standard deviation; UC, ulcerative colitis.