Table 1.
Baseline clinicopathological characteristics
| Total no. (%) | |
|---|---|
| All | 100 |
| Sex | |
| Male | 78 |
| Female | 22 |
| Age at primary diagnosis (median, years) | |
| All | 66 |
| Male | 67 |
| Female | 66 |
| Location of primary tumor (includes material used for PD‐L1 analysis) | |
| Lower urinary tract, bladder | 88 |
| Upper urinary tract, renal pelvis/ureter | 12 |
| T‐stage | |
| pT1 1 | 16 |
| pT2 | 65 |
| pT3 | 6 |
| pT4 | 8 |
| Unknown | 5 |
| Histological subtype | |
| Urothelial carcinoma (UC) NOS 2 | 66 |
| UC with squamous differentiation 3 | 14 |
| UC with divergent histological differentiation 4 | 20 |
| Location of available metastatic tissue used for PD‐L1 analysis | |
| Lymph node pelvis/perivesical | 38 (69%) |
| Visceral/bone metastasis 5 | 17 (31%) |
| Time from primary tumor to metastasis | |
| Synchronous metastasis (−5 month to 3 month) | 32 |
| 4–6 months | 7 |
| 7–12 months | 8 |
| >1 year | 8 |
1
Includes 3 case with pT1a tumors, 9 cases with pT1b and 3 cases with pT1 tumors not further subclassified.
2
Defined as pure infiltrating UC.
3
Defined as the presence of infiltrating UC and squamous differentiation in the same tumor.
4
Includes UC with divergent histological features including one or more of the following: Plasmacytoid‐, neuroendocrine‐, sarcomatoid‐, glandular‐, clear cell‐ and lymphoepithelioma‐like differentiation along with poorly differentiated UC.
5
Includes a total of two cases diagnosed with bone metastasis.