Table 5.
Patient characteristics according to PD‐L1 expression and FGFR 1–3 aberrations in primary tumor tissue
Patient nr. | Age | Gender | Primary tumor | Stage | Histology | PD‐L1 CPS score | FGFR 1 1–3 aberrations |
---|---|---|---|---|---|---|---|
FGFR1 aberrations | |||||||
1. | 69 | M | Bladder | pT2 | UC NOS | 0.5 | Mutation p.D585H |
FGFR2 aberrations | |||||||
2. | 64 | M | Bladder | pT2 | UC NOS | 10.0 | FGFR2 amplification (copies 16) |
3. | 75 | M | Bladder | pT2 | UC DHD 2 | 5.5 | Mutation H254Y |
FGFR3 aberrations | |||||||
4. | 63 | F | Bladder | pT1 | UC NOS | 1.9 | Mutation p.G370C |
5. | 59 | M | Bladder | pT2 | UC NOS | 1.4 | FGFR3 amplification (copies 10) and Mutation p.Y373C |
6. | 71 | M | Bladder | pT2 | UC NOS | 11.2 | FGFR3 amplification (copies 9) |
7. | 56 | F | Bladder | pT2 | UC SD 3 | 13.1 | FGFR3 amplification (copies 5) |
8. | 53 | F | Renal pelvis | pT4 | UC NOS | 0.1 | FGFR3 amplification (copies 33) |
9. | 73 | M | Bladder | pT2 | UC NOS | 0.5 | FGFR3 amplification (copies 23) |
10. | 66 | M | Renal pelvis | pT4 | UC NOS | 4.6 |
FGFR3 amplification (copies 9) FGFR1 amplification (copies 6) |
11. | 69 | M | Renal pelvis | pT3 | UC NOS | 0 | FGFR3 amplification (copies 14) |
12. | 69 | M | Ureter | pT3 | UC NOS | 4.4 | FGFR3 amplification (copies 5) |
13. | 61 | M | Bladder | pT1b | UC NOS | 5.4 | Mutation p.R248C |
14. | 62 | M | Bladder | pT2b | UC DHD 2 | 4.5 | Mutation p.S249C |
15. | 52 | F | Renal pelvis | pT4 | UC DHD 2 | 0.4 | Mutation p.R248C |
16. | 81 | F | Bladder | pT2 | UC NOS | 1.9 | Mutation p.Y373C |
17. | 71 | M | Bladder | pT1 | UC NOS | 0.2 | Mutation p.Y373C |
Fibroblast growth factor receptor.
UC DHD, Urothelial carcinoma with divergent histological differentiation.
UC SD, Urothelial carcinoma with squamous differentiation.