Table 2.
Summary of oncological outcomes
| Authors | Surgical procedure | No. of patients | Median age | ypT0 (%) | 5y‐DFS (%) | 5y‐OS (%) | 3y‐DFS (%) | 3y‐OS (%) | LR (%) | DR (%) | 30‐day mortality | 90‐day mortality |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lezoche et al. 21 | NAT + LE | 50 | 66 (58–70) | 14 (28) | 89 | 72 | 4 (8) | 2 (4) | 0 | |||
| TME | 50 | 66 (60–69) | 13 (26) | 94 | 80 | 3 (6) | 2 (4) | 0 | ||||
| Jawitz et al. 22 | NAT + LE | 695 | 63 (16) | 77.7 | 5 (0.7) | 10 (1.4) | ||||||
| TME | 6629 | 66 (20) | 75.1 | 86 (1.3) | 176 (2.7) | |||||||
| Lynn et al. 24 | NAT + LE | 79 | 62.7 (11.24) | 38 (50) | 88.2 | 90.3 | 3 (4) | |||||
| TME | 79 | 64.4 (11.25) | 88.3 | 88.4 | 1 (1.3) | |||||||
| Pericay et al. 25 | NAT + LE | 15 | 76 (57–87) | 4 (26.7) | 91 | 73 | 0 | 1 (6.7) | ||||
| Garcia‐Aguilar et al. 26 | NAT + LE | 79 | 62 (30–83) | 38 (49) | 86.9 | 95.7 | 3 (4) | 5 (6) | ||||
| Noh et al. 27 | NAT + LE | 17 | 63 (38–79) | 10 (59) | 82 | 2 (11.7) | 2 (11.7) | |||||
| Shin et al. 28 | NAT + LE | 34 | 63.6 (36–83) | 19 (55.9) | 97.1 | 100 | 1 (2.9) | 1 (2.9) | ||||
| Yu et al. 29 | NAT + LE | 18 | 9 (50) | 0 | 1 (5.5) | |||||||
| Guerrieri et al. 30 | NAT + LE | 185 | 68 (60–74) | 63 (34.1) | 93 | 50 | 24 (13) a |
a
Local and distant recurrences.
DFS, disease‐free survival; DR, distant recurrence; LR, local recurrence; OS, overall survival.