Figure 7.
(a) Mpeg1 is not involved in the control of LCMV infection. Nine mice of each genotype were infected with 2 × 106 FFU of LCMV Docile strain intravenously and viral titers in tissues assessed at day 8 or 28. Each point indicates a single mouse. The experiment was carried out two times. (b) Mpeg1 does not influence the antibody response. Six mice of each genotype were injected with 10 μg ovalbumin–adjuvant mixture subcutaneously on day 0. In the experiment shown in the lower panel, mice received a boost at week 6. Sera were collected and checked for antibody level at the indicated times using an indirect ELISA assay. Data represent two independent experiments: each point indicates a single mouse. Statistical significance was assessed using the Student's t‐test with Holm–Šídák correction for multiple comparisons. ns = P > 0.05. FFU, focus‐forming unit; KO, knockout; LCMV, lymphocytic choriomeningitis virus; Mpeg1, macrophage‐expressed gene 1; WT, wild type.