Signalling questions	Description	Response options
5.1 Was the trial analysed in accordance with a pre‐specified plan that was finalized before unblinded outcome data were available for analysis?	Trial registration: ClinicalTrials.gov identification number NCT00426010 There were no changes to study outcomes after study commencement	Y
Is the numerical result being assessed likely to have been selected, on the basis of the results, from…
5.2. … Multiple outcome measurements (e.g. scales, definitions, time points) within the outcome domain?	Measure of fatigue, energy, nausea, systolic blood pressure and conclusion according to results of energy and fatigue only, while no tests found significant difference	Y
5.3 … Multiple analyses of the data?		PN
Risk‐of‐bias judgement		High

Note: PN, Probably No; Y, Yes.