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(a) Facial features and pedigree of individuals 1.1, 2.1, 2.2, and 3.1 at different ages. (b) RPL10 tolerance landscape showing the variant p.(Arg32Leu) in high intolerance domain. (c) The variant p.Arg32Leu affects the neutral charge of leucine disrupting the interaction with Asp28 residue, and RPL10 conformation and electrostatic interactions with the RNA molecules (PDB 5AJ0)
