Skip to main content
. 2022 May 25;36(9):1524–1540. doi: 10.1111/jdv.18210

Table 1.

Follicular adnexal tumours. 86 cases in 54 articles a

Benign Cases/Articles (81/51) M/F (41/30) Age range (4/93) Max diameter range (1–30) Clinical morphology aspect Dermoscopy
Basaloid follicular hamartoma 3/31,33,121 3/0 14–64 3–7 2 HN and truncal papules in 2 Indian patients with multiple lesions
  • 1: pinkish background, blue‐grey and brown globules, linear irregular vessels

  • 1: papillomatous and cobblestone pattern, brown‐black globules and dots and comedo‐like openings

Solitary HN macule in a 64 y/o patients from Singapore
  • 1: homogenous structureless blue pigmentation, no visible vessels

Inverted follicular keratosis 12/49,76,101,184 8/4 29–93 4–12 1 HN pigmented macule (black and brown) in a 93 y/o woman
  • 1: eccentric black blotches and brown lines, no visible vessels

11 solitary nonpigmented pink‐reddish papules (6) and nodules (5), mainly on the HN (6) and limbs (3 upper, 3 lower). Patients were all Caucasians.
  • 6: pink‐white background + central crust (2) or ulceration (2) or whitish/orange structureless areas (2); vessels: mostly hairpin peripheral

  • 2: yellow central keratin mass, white structureless areas, scales and blood spots, polymorphous radial vessels (hairpin, comma, glomerular and linear irregular) surrounded by a white halo

  • 2: peripheral hairpin vessels surrounded by a white halo, central white‐yellow amorphous area with polymorphous vessels (glomeruloid with white halo, linear irregular, dotted)

  • 1: papillomatous surface, central dotted vessels surrounded by white halo

Tumour of the follicular infundibulum 2/1140 1/1 53–54 5–11 2 pinkish macules on lower limbs and trunk of 2 Caucasian patients
  • 1: pinkish background and white lines; short peripheral linear vessels and dotted or more convoluted in the central part

  • 1: white central lines, homogenous brown pigmentation

Trichilemmoma (1 desmoplastic) 7/5 40,77,86,105,128 4/3 6/84 3/10

5 solitary, 2 multiple (Cowden syndrome).

All nonpigmented HN papules, except one keratotic horny plaque in a 6 y/o Asian girl, on a sebaceous nevus.

All with 2 concentric areas:
  • Central: whitish structureless, umbilicated or hyperkeratotic

  • Peripheral: pinkish‐reddish, with red ‘iris‐like structures’ (3), b or short linear or crown vessels (4)

Trichoadenoma 2/2115,139 1/1 45/65 5/6 2 solitary HN pinkish papules
  • 1: pink‐yellow background, multiple roundish white structures surrounded by thin linear and arborizing unfocused vessels

  • 1: multiple small roundish white structures, diffuse unfocused linear vessels; 1 blue‐grey globule peripheral

Trichofolliculoma 2/2141,66 2/0 48–62 8–10 2 HN brownish‐pinkish nodules
  • 1: ‘firework pattern’: central brown area with radial dark brown projections assuming a crown shape (coarse granules), with no pigment network; no visible vessels

  • 1: bluish nodule with a white central area, shiny white structures, dotted vessels and a central scale

Trichoepitelioma desmoplastic 5/58,46,91,97,136 2/1 16–83 2–14 5 solitary whitish‐pinkish plaques
  • All white background (ivory in 3) + white‐yellow clods/globules (4). Vessels: fine arborizing (3), linear crown (1), linear/serpentine (1)

Trichoepitelioma 9/98,49,64,99,100,127,161,174,181 3/5 8–60 3–10

All HN papules: 7 white‐pink; 2 brown‐blue.

4 patients had multiple lesions (1 Brooke‐Spiegler syndrome; 1 multiple familial trichoepithelioma)

  • 7: whitish background + multiple white roundish structures

  • 2: pigmented structures: blue‐grey ovoid nests and peripheral dots (1); brownish background, irregular brown globules and blotches (1)

  • Vessels: arborizing thin with a few branches (7); short fine (2)

Trichoblastoma (1 adamantinoid) 16/969,94,97,145,146,149,150,159,202 5/6 22–77 1–20

1 patient with multiple nodules on HN and trunk

15 solitary nodules or plaques, mainly on HN, of which 9 pigmented (blue‐grey).

6 on sebaceous nevus

  • 10: pigmented criteria: 5 blue‐grey homogenous areas (3 symmetrical); 3 blue ovoid nests; 2 homogenous brown areas

  • Other criteria: yellow clods, chrysalis and white‐yellow structureless areas

  • 6: pinkish background (described as pearly in 2 cases and with an orange hue in 1 case)

  • Other criteria: Milky‐red areas, thick white streaks and short fine radial linear vessels with a crown distribution in 1 case; central whitish veil surrounded by unfocused arborizing vessels not crossing the center of lesion in 1 case.

Fibrofolliculoma and Trichodiscoma (1 mixed) 5 (4 patients)/248,84 3/1 35–72 4

All pink‐red papules

1 on HN of a 72 y/o Caucasian woman, 3 on HN and 1 on trunk of 3 Asian patients with Birt‐Hogg Dubè syndrome

  • All pinkish‐whitish background

  • 4 pigmented criteria: brown globules (2), brownish background (2)

  • Vessels: linear irregular and dotted (1); linear (1)

Panfolliculoma 1/1103 1/0 60 7 Pink‐reddish truncal nodule
  • White central part with some crusts; peripheral unfocused thin arborizing low branching vessels not crossing the center

Pilomatricoma (2 anetodermic; 1 bullous) 16/123,12,28,68,86,93,97,111,115,182,194,200 7/8 4–75 4–30

All solitary nodules, mainly on HN (12) and upper limbs (3).

4 pigmented (blue).

1 on sebaceous nevus

  • 5: red‐blue background + yellow structureless areas (2) and ulceration (2). Vessels: linear irregular (3), tortuous (1), polymorphous (1)

  • 3: pink background and white roundish structures + peripheral blue homogenous areas (2). Linear irregular (2) or polymorphous (1) vessels.

  • 4: milky‐ or purple‐red background, yellowish structureless areas, linear irregular vessels or arborizing vessels + white streaks (2) and blue‐grey globules (1)

  • 2: blue‐red areas and linear irregular vessels + white streaks and ulceration (1) or white‐yellow ovoid nests (1).

  • 1: ‘fishing net‐like’ pattern: white interlacing lines surrounding red globules

  • 1: clear lobular structure, homogenous yellow and pink areas, yellowish globules and white scales

Melanocytic matricoma 1/1138 1/0 65 10 Blue nodule on upper limbs of a Caucasian patient
  • central white‐blue structureless area, peripheral pink background and structureless brown areas. Polymorphous vessels: dotted, linear irregular, hairpin and glomerular

Malignant Cases/Articles (5/4) M/F (4/0) Age range (58/72) Max diameter range (10–40) Clinical morphology aspect Dermoscopy
Pilomatrix carcinoma 1/1155 1/0 69 14 Solitary HN red‐purple nodule
  • 1: white irregular areas, surrounded by homogeneous structureless purple/red areas. Fine arborizing and linear irregular vessels

Trichilemmal carcinoma 3/210,97 2/0 65–72 10–40 Solitary HN pink‐red nodules, 2 ulcerated
  • 3: white‐pink background with polymorphous vessels (dotted glomerular, linear irregular and tortuous) + yellow crusts in 1 case

Trichoblastic carcinoma 1/1205 1/0 58 20 Ulcerated HN blue‐grey nodules
  • 1: heterogeneous pigmentation with blue and black pigmented areas with a whitish veil

HN, head and neck.

a

See eReferences.

b

Iris‐like structure: radial morphology aspect with erythematous radial lines surrounded by white shiny areas, the redlines appeared thickened and highlighted at their outer end, presenting as red triangles or red projections.