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. 2022 May 25;36(9):1524–1540. doi: 10.1111/jdv.18210

Table 2.

Sebaceous adnexal tumours. 69 cases in 34 articles. a

Benign Cases/Articles (50/29) M/F (18/14) Age range (1/93) Max diameter range (2–80) Clinical morphology aspect Dermoscopy
Folliculosebaceous cystic hamartoma 2/22,192 1/1 29–44 5–15 Pink‐white HN nodules in 1 Asian and 1 Indian patient
  • 1: crown vessels + multiple oval‐round yellow‐white structureless areas rimmed by normal pseudo‐reticular pigment network + smaller yellow‐orange dots

  • 1: pinkish background, central brownish pigmentation, brown dots, yellow globules and white scales, with no visible vessels

Reticulated acanthoma with sebaceous differentiation 4/481,125,134,156 3/1 58–93 11–45

3 plaques, 1 macule.

3 pigmented (2 lower limbs, 1 trunk): brown‐red or ‐orange; 1 nonpigmented (red‐yellow)

  • 2: yellow reticular structure over a pinkish background + multiple erosions and peripheral brownish pigmentation (1), dotted, glomerular vessels and white scale (1)

  • 1: irregular pigmentation with yellow dots with linear or reticular arrangement + dotted and comma‐like vessels

  • 1: central inverse network (white lines) and peripheral brown pigmentation

Sebaceoma 7/622,42,119,133,151,202 2/5 40–81 4–25

Solitary pink‐red nodules (4), papules (2), plaque (1), mainly on HN.

1 pigmented (dark brown‐blue).

1 on sebaceous nevus

1 patient with Muir‐Torre syndrome

  • All: yellow structures (homogenous structureless areas and/or yellowish roundish) and whitish areas + central ulceration (3)

  • 2: pigmented structures: brown‐grey structureless area (1), asymmetric follicular openings (1)

  • Vessels: peripheral and thin arborizing (4), linear crown (1) or polymorphic (2)

Sebaceous adenoma 6 (3 patients)/392,109,119 0/1 79 10 Solitary pink‐yellow truncal nodule (Afro‐American woman)
  • 1: pinkish background, yellow‐white globules, ulceration and atypical vessels (linear irregular and hairpin)

1/0 64 7 5 in 2 patients with Muir‐Torre syndrome with multiple pink‐yellow HN and truncal nodules
  • 2: yellow structureless and ovoid areas + pinkish background and crown or unfocused arborizing vessels

  • 3: crateriform appearance with a central ulcerate or keratotic areas + pinkish‐whitish background and peripheral linear crown vessels.

Sebaceous hyperplasia 11/721,59,64,92,137,163,199 5/3 29–70 2–6

10 nonpigmented yellow‐orange papules and 1 bluish papule, mainly on HN.

3 patients had multiple lesions

  • All: whitish‐pinkish background with whitish and yellowish globules and clods + central depression (4) (umbilicated center), bonbon toffee sign (2), cumulus sign (2) b

  • Vessels: mostly linear and crown

Sebaceous nevus 19/6 6,53,90,92,129,186 (+20/11 associated with another AT) 5/3 1–25 7–80 All HN solitary pink‐yellow plaques; 3 pigmented with brown colour
  • Global pattern: cobblestone (2), cerebriform (2), papillomatous (3), lobular (1)

  • All: yellow‐white to brown background, with yellow‐white‐red to brown dots/globules in 14 cases.

  • 1: Milia‐like cyst and comedo‐like openings

  • Vessels: no visible (9), linear irregular (4), arborizing (3) glomerular surrounded by white halo (1)

Steatocystoma multiplex 1/1 174 1/0 28 n.r. Yellowish HN nodule (Indian)
  • Yellowish structureless pattern composed by roundish yellowish structures, no visible vessels

Malignant Cases/Articles (19/8) M/F (11/8) Age range (40/102) Max diameter range (3–40) Clinical morphology aspect Dermoscopy
Sebaceous carcinoma 19/8 31,37,79,97,118,124,152,165 11/8 40/102 3–40

All solitary nodules, mostly ulcerated (13) and located on HN (14). 16 pink‐red or yellow; 2 pigmented.

9 in Asian patients, 1 with Muir‐Torre syndrome. 1 on sebaceous nevus

  • Mostly pink‐whitish and yellowish background, yellow clods and globules and ulceration

  • 2: blue ovoid nests and bluish structureless areas

  • Vessels: polymorphous (9), linear irregular and crown (9)

HN = head and neck; n.r. = not reported.

a

See eReferences.

b

well‐defined milky‐white cloud‐like structures.